Initially, the drug enters cells through the plasma membrane monoamine transporter (PMAT) and organic cation transporter 3 (OCT3) located on the surface of small intestinal epithelial cells
Rather than being a monolithic wall-like structure, however, the intestinal barrier consists of numerous specialized components and heterogeneous cell types and intercellular junctions that achieve this function [6, 7]
10.1021/jf200251k J
Indeed, GSH decrease causes protein nitration, S -nitrosylation, and DNA strand breaks in neuronal cells
Moreover, chondrocyte apoptosis, triggered by ER stress, nitric oxide, and oxidative insults, plays a critical role in cartilage degradation
Singh KK, Kapoor A, Khanna R, Sahu A, Kapoor V, Kumar S, et al