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Effectiveness depends on your genetic sensitivity and adherence to diet, not on side-effect intensity

Avoid drinking large volumes with meals, as this can increase feelings of fullness and discomfort

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Patients on biologic immunosuppressants (infliximab, vedolizumab, ustekinumab) should avoid GLP-1 therapy unless their gastroenterologist explicitly approves, since combining immune-modulating drugs increases infection and flare risk