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The Pharmacology of Liraglutide and Semaglutide Liraglutide and semaglutide are both long-acting GLP-1RAs that, despite differing administration intervals and doses, have pharmacodynamic (PD) effects for 24 h/day (124, 125)

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Clinical trials have shown that, in combination with lifestyle changes, Semaglutide or Tirzepatide can lead to substantial weight loss, making it a cornerstone in our arsenal of treatment options

Diabetes Ther 14(4):777786 Ceasovschih A, Asaftei A, Lupo MG, Kotlyarov S, Bartuskova H, Balta A et al (2025) Glucagon-like peptide-1 receptor agonists and muscle mass effects