Authorship note: BW and COS are cofirst authors
Higher doses (600-1000mcg) are not well studied and may increase costs significantly while potentially causing more side effects
10.1016/0003-2670(93)80373-s 713 WyttenbachT.Von HeldenG.BowersM
Ageing Res Rev 26:8195 Li J, Ichikawa T, Villacorta L, Janicki JS, Brower GL, Yamamoto M, Cui T (2009) Nrf2 protects against maladaptive cardiac responses to hemodynamic stress
10.1038/nm.4464 177 SeltzerM
Additionally, Mounjaro , one of the newer diabetes drugs, which was approved in May 2022 and has a unique dual mechanism of action (it activates the GLP-1 hormone as well as another hormone called the glucose-dependent insulinotropic polypeptide or GIP, both helping to improve blood sugar) may be even more effective than semaglutide in reducing weight