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BMJ Open 14 (2), e074391

In 2025, 52% of Americans said they would like to lose weight, according to a Gallup survey

This growth is fueled by increased access through online pharmacies, where around 500,000 individuals are bypassing NHS (National Health Service) channels

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However, both drugs independently reduce appetite and fluid intake, creating an additive risk for dehydration, electrolyte imbalances, and acute kidney injury in vulnerable populations

In addition, semaglutide helps burn more fat by supporting metabolic processes that increase fat oxidation