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van Zandwijk 1995

Glutathione deficiency can worsen liver stress

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Conversely, Nrf2 has been documented to reduce NOX activation and inhibit protein kinase C, consequently leading to a decrease in ROS levels and production in Nrf2-KO mice due to elevated antioxidant GSH levels, highlighting its role in mitigating oxidative stress

doi: 10.1016/0024-3205(66)90099-3 30 ReiterRJ

Inflammatory response mechanisms always include pattern recognition of cell surface receptors to detrimental stimuli, activation of inflammatory pathways, and recruitment of inflammatory cells to the damaged organ (Chen et al