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GLP-1Rx Program Telehealth for Branded Med Lose 37% more weight with Noom habits* Branded prescription, pickup or pharmacy-delivered Including clinical care, prescription and digital program

Key considerations when switching: Allow a washout period based on tirzepatide half-life Start retatrutide at the standard 1mg initiation dose regardless of previous tirzepatide dose Expect renewed GI side effects as the glucagon receptor is a new stimulus Monitor heart rate more carefully during the initial escalation period When tirzepatide is the better choice Tirzepatide remains the superior option in several specific situations

Weight loss plateaus during the second half of year one, but it does not significantly reverse as long as treatment continues

Are there opportunities to use GLP-1 medicines for addiction or other behavioral conditions

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[2] [13] GLP-1 also increases [14] cell mass by promoting proliferation and neogenesis while inhibiting apoptosis