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In nonneuronal tissues, experimental studies have demonstrated that melatonin inhibits NO production induced by lipopolysaccharide (LPS) that induce the activation of the immune response 77

The study confirmed FOXO4-DRI was effective across senescent cells generated by different methods (irradiation, doxorubicin, and replication stress), and documented that pre-treatment with FOXO4-DRI attenuated the dedifferentiation of chondrocytes during in vitro expansion establishing it as a valuable tool for research into senescent cell biology in cartilage and musculoskeletal models

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November 27, 2014 [October 31, 2023]

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