Imagine you are trying to send a fragile glass ornament through the mail during a heavy storm
OXIDATION TOXIC PATHWAY (CYP2E1 enzyme) Only 5-10% of acetaminophen in healthy non-pregnant adults INCREASES by 80% during pregnancy[] Creates NAPQI (N-acetyl-p-benzoquinone imine)the toxic metabolite NAPQI formation 43% HIGHER in first trimester[] NAPQI must be immediately neutralized by glutathione When glutathione is depleted, NAPQI causes cellular damage Crosses the placenta and damages fetal brain HOW PREGNANCY CHANGES ACETAMINOPHEN METABOLISM METABOLIC PATHWAY CHANGES DURING PREGNANCY[] Human pharmacokinetic studies reveal dramatic shifts in how pregnant women metabolize acetaminophen: Oxidation to NAPQI (Toxic Pathway) INCREASES by 80% The Brookhuis et al
J Nanobiotechnol 18:117 Gndodu R, Erkan M, Aydn M, Snmez MF, Vural A, Kkolu K, Karabulut D, ahin M (2019) Assessment of the effectiveness of quercetin on cisplatin-induced ototoxicity in rats
The Effects of Semaglutide vs Testosterone Replacement Therapy on Functional Hypogonadism and Sperm Quality in Men with Type 2 Diabetes Mellitus and Obesity. Endocrine Abstracts , vol
That is why they are widely used to treat diabetes and support weight loss
Where is glutathione found in the body
