While preclinical and early clinical studies have suggested that autophagy inhibition may enhance the therapeutic efficacy of MEK1/2 or ERK1/2 inhibition, 24,44 real-life data have thus far not supported the reliable impact of trametinib + hydroxychloroquine for the treatment of metastatic PDAC
doi: 10.3390/molecules26020302, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 29.Molloy JW, Barry D
Whether youre unsure about which medicine is right for you or need help navigating the world of weight loss drugs, our team are on hand to help you make the right decision
MOMP, cell suicide as a BCL-2 family business
As drugs become more available, equitable access to these treatments should be prioritised to meet the needs of all population groups, particularly those who may face barriers to access despite high interest
For NFS1 knock down, the following shRNAs were used: shNFS1_1, TRCN0000229753, B4: shNFS1_2, TRCN0000229755, B6 (Addgene)
