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The inherent limitations of animal models in fully capturing the heterogeneity and complexity of AD in human necessitate carefully designed clinical trials with well-defined patient populations and outcome measures

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doi: 10.1097/00007611-198411000-00007 141 TobiMMoragARavidZChowersIFeldman-WeissVMichaeliYet al

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These findings suggest that metformin not only alters hepatic metabolism but also significantly affects the gut microbiota and systemic metabolic processes, contributing to its therapeutic effects in MAFLD