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Bypassing GSSG recycling restores proteostasis Collectively, our data show that G6PDH deletion in growth plate chondrocytes decreases NADPH levels and the GSH:GSSG ratio, resulting in increased ROS levels, altered proteostasis and increased lipid peroxidation and ferroptosis

Cardiac conduction improvement in two heterozygotes for primary carnitine deficiency on L-carnitine supplementation

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Antioxidants help maintain cellular balance by stabilizing these reactive molecules without becoming unstable themselves

The magnitude of change in cell function produced by exendin 9-39 was unaffected by acute FFA elevation