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The bottom line Basal insulin and GLP-1 combinations like Xultophy and Soliqua can be a great option for managing type 2 diabetes

In addition to phagocytosis and increased lysosomal enzyme activity, both medications dramatically increased peritoneal macrophage recruitment and activation

However, follow-up studies indicate that nearly 10% of individuals treated with ESAs develop resistance, a condition often linked to iron deficiency and systemic inflammation (van der Putten et al., 2008

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doi: 10.1016/j.bbrc.2016.05.019 35

This interaction establishes a self-perpetuating cycle: uremia-induced inflammation hastens erythrocyte apoptosis, and apoptotic cell materials further stimulate immune activation and additional cytokine secretion (Paulson et al., 2020)