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Gomez-Pinilla F, Yang X

NMDA Receptor Modulation In brain research models, DSIPs effects appear to be at least partly mediated via NMDA receptors a glutamatergic ionotropic receptor family central to synaptic plasticity, learning and memory, and excitatory neurotransmission

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Patients suffering from major depression had reduced levels of immunoreactive DSIP compared to control subjects, as shown in cerebrospinal fluid (CSF) analysis

Interestingly, some in vivo IVD regenerative studies have been performed with laboratory dogs with experimentally induced IVD degeneration [2126]