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Some patients may have compensatory mechanisms that maintain hunger signals despite GLP-1 receptor activation

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Upon sequencing, the region was found to span 548 bp with the proximal breakpoint located between positions 13389-13936 in CEL and the distal breakpoint between positions 29161-29707 in CELP (GenBank accession AF072711.1)

In contrast, LepR is expressed in sub-populations of neurons located in the lateral hypothalamus (136138) a region known to directly and indirectly influence the histaminergic neurons (139, 140)

Its synthesis is catalyzed first by glutamate cystine ligase (GCL), which couples to ATP hydrolysis to form an amide bond between the carboxyl group of glutamate and the amino group of cysteine