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When SAM is reduced from MTHFR-impaired methionine regeneration, EZH2 and other histone methyltransferases lose substrate availability producing progressive loss of repressive histone methylation marks at senescence-promoting gene promoters

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A recent study reported significant increase of SOA in plasma samples of RPL patients compared to the control samples (45.2 6.10 nmol/ml vs 35.3 5.45 nmol/ml)

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