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Annual Review of Pharmacology and Toxicology , 53 , 401426

doi:10.1631/jzus.B1200348

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Primary testicular cell cultures, including isolated Sertoli cells and spermatogonial stem cells, provide tractable systems for investigating EED effects on specific cellular functions

SELENOP is essential for selenium supply to the testes, and animal models lacking the SELENOP gene are infertile due to poor selenium tissue bioavailability, defective GPx4 synthesis, and impaired sperm maturation (7)