If it has beta-carotene as the source, you can take upward of 25,000IU without any adverse side effects
These pathological pathways are probably mediated, at least in part, through NLRP3 inflammasome stimulation and mitochondrial disruption
If you choose to drink, limit to 1 drink maximum, choose lower-calorie options (dry wine, light beer, spirits with soda water), drink very slowly with food, stay well-hydrated with water between sips, and never drink on an empty stomach
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Retinal photography programs can be alternative screening strategies
Curr Opin Clin Nutr Metab Care, 2002