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Pickart's foundational work and subsequent studies on copper peptides and wound closure point to upregulation of matrix metalloproteinases, the enzymes responsible for remodeling collagen into organized structure during repair, rather than the disorganized collagen deposition that produces visible scarring

Mol Biol Rep

L., Johnson R

These are not minor improvements

Y., Smakhtin M

View Study [4]"The effect of topical tripeptide-copper complex on healing of ischemic open wounds" Canapp SO, Farese JP, Schultz GS, Gowda S, et al., 2003 Finding: Topical GHK-Cu dramatically accelerated wound healingwounds shrank by 64.5% in the treatment group versus only 28.2% in controls by day 13