Together, these delayed and/or reduced inductions of crucial cell cycle regulators in early and mid-late G1 demonstrate that the G0/G1 transition, the progression beyond the mitogen-dependent restriction point and the G1/S transition were significantly altered by the absence of GSTP1/2
10.1371/JOURNAL.PONE.0056625 188 VargasM
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Applications in biomedical research and targeted therapy Importance of co-activators in disease research and drug discovery TFs, in order to swiftly integrate cellular stimuli, must have the ability to rapidly recruit multiple proteins associated with transcription machinery using single short domains
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Products that meet all four are more likely to deliver the modest, real benefits described in the clinical literature