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The post hoc analysis of pooled data from the Semaglutide Treatment Effect in People with Obesity (STEP) 1, 2, 3, and 5 trials indicated that semaglutide treatment at 2.4 mg did not increase the risk of depressive symptoms or suicidal ideation compared to placebo, while demonstrating a statistically significant yet clinically negligible decrease in depressive symptoms [75]

We also weighed real-world feedback

BMJ 381 , e074572 (2023)

While pharmaceutical interventions for enhancing GLP-1 activity exist, exploring natural sources offers a holistic and more sustainable approach to metabolic health

This will come as great news for patients who have wanted to try GLP-1 treatments but were needle averse

(2025, December 11)