New data from a massive cohort study of 2 million patients published in Nature Medicine in January 2025, suggest that GLP-1 medications may actually reduce the risk of substance use disorders , including Cannabis Use Disorder (CUD)
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The most commonly reported side effects during the first month are gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, consistent with other GLP-1-containing therapies
This means that it has no recognized medical use and is considered to have a high potential for abuse
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