The best-known ones are liraglutide (Victoza) and semaglutide (Ozempic, Wegovy, Rybelsus)
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Eli Lilly's TRIUMPH program includes trials covering obesity, cardiovascular disease, knee osteoarthritis, and long-term cardiovascular outcomes
Notably, oral semaglutide has compared favorably when studied head-to-head against a variety of agents, including an SGLT-2 inhibitor and injectable liraglutide
The long-term clinical significance is not yet established and is a specific focus of the ongoing phase 3 and cardiovascular follow-up program
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