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It is currently available only within clinical trials, and any use outside a trial setting would be considered off-label and is not recommended

Beyond appetite, tirzepatide improves insulin sensitivity

Slower dose escalation can also help

This includes an increasingly popular type of weight loss drug called semaglutide, widely known under brand names including Ozempic and Wegovy

The FDA has approved its use for chronic weight management in adults with a body mass index (BMI) of 30 or more, or a BMI of 27 or more when accompanied by at least one weight-related condition such as high blood pressure, high cholesterol, or type 2 diabetes

For most households, this represents a substantial portion of annual income