Antioxidant Defense and Redox Balance Glutathione serves as the bodys primary intracellular antioxidant by neutralizing reactive oxygen species (ROS) and other free radicals generated during normal cellular metabolism
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Sartoretto JL, Melo GA, Carvalho MH, Nigro D, Passaglia RT, Scavone C, et al
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The review also documented how GCL expression is transcriptionally upregulated by electrophiles through antioxidant response elements (ARE/EpRE) in the GCLC and GCLM promoters establishing the Nrf2/ARE pathway as the master regulator of GSH biosynthetic capacity under stress conditions