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More significant changes in firmness, fine lines, and pigmentation typically appear after 8 to 12 weeks of consistent use

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L.RockensteinE.ManteM.AdameA.OverkC.SpencerB.et al (2016)

Counsel patients to report symptoms of thyroid tumors (e.g., a lump in the neck, persistent hoarseness, dysphagia, or dyspnea) to their healthcare provider [see Boxed Warning and Warnings and Precautions (5.1)]