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A dose of 5 mg is highly toxic, and chronic low-level exposurehistorically, seen in certain industrial settingscaused weight loss, anemia, dermatitis , and severe social isolation due to the unbearable odor emitted by affected individuals

Lithium : Used for bipolar disorder, lithium can trigger acne

Nat Med 28(3):591598

Glutathione neutralizes the harmful effects of free radicals

The extract also showed inhibition on the release of inflammatory enzymes (COX-2, iNOS, and MMP-9) by inhibiting LPS-induced activation of JAK/STAT and TLR4 pathways, particularly JNK, p38, IB, and STAT phosphorylation