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Tissue-Specific Effects Tendon and Ligament Healing BPC-157 accelerates tendon and ligament repair through enhanced fibroblast proliferation and collagen synthesis, primarily via focal adhesion kinase (FAK)-paxillin signaling pathways [24, 26, 53]

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Aortic tissue LOXL2 activity assay Aortas from young ( 18 months old) WT and LOXL2+/ littermates were extracted and cleaned free of connective tissue in Krebs-HEPES buffer (NaCl 135 mM, KCl 5 mM, MgSO 4 1 mM, K 2 HPO 4 0.4 mM, Glucose 5.5 mM, HEPES 20 mM, adjust the pH to 7.4, supplement with 1 mM CaCl 2 ) containing 0.25 g/mL fungizone (Gibco)

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