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Native GLP-1 lasts only minutes because the enzyme DPP-4 degrades it almost immediately
Targeting the gastrointestinal tract to treat type 2 diabetes
Cotter, L., Rae, M., McGough, M., Panchal, N., et al
Studies show impaired hepatic mitochondrial function in obesity and insulin resistance models induced by high-fat or high-fructose diets
The SURMOUNT trials in patients without diabetes showed even greater weight loss, with the 15 mg dose producing an average loss of 20.9 percent of body weight at 72 weeks compared to 14.9 percent for semaglutide in similar populations