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American journal of physiology Regulatory, integrative and comparative physiology

Retatrutide is an investigational injectable medicine being developed primarily for the treatment of obesity and type 2 diabetes

Participants had normal vital signs, 12-lead electrocardiogram results and clinical laboratory tests at the time of randomization

Always report suspected side effects via the MHRA Yellow Card scheme

According to Lillys release, the trial met its primary endpoint: participants titrating up to the highest orforglipron dose lost 27.3 lb (12.4%) of body weight at 72 weeks versus about 0.9% weight loss with placebo

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