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Review Articles Hartl DM, Rao KN, Coca Pelaz A, Rinaldo A, Zafereo ME , Randolph GW, Nixon IJ, Hamoir M, Robbins KT, Kowalski LP, Asciak PP, Soudi B, Rodrigo JP, Ferlito A

Both COPD and lung cancer show a separation in the time between the exposure and actual disease symptoms, which for COPD can be 30 years or more

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This increases cost without clear benefit and eliminates the ability to increase dose if initial response is insufficient