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GLP-1/GIP weight loss program also triggers the release of more adiponectin , a hormone that fights against inflammation, enhances insulin sensitivity, and helps prevent the onset of diabetes and cardiovascular disease

This is important as it shows that specific changes in human gut microbiota can be linked to dietary patterns and may be relevant to the etiology of MASLD (90)

3.6 Neutrophils Neutrophils are a crucial component in the TME, exhibiting significant phenotypic and functional heterogeneity to either exert antitumor effects or promote tumor progression via multiple mechanisms

Probiotics and intestinal health effects: a clinical perspective

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Research shows that 25 to 40% of weight lost on GLP-1 medications like semaglutide and tirzepatide can come from lean muscle tissue, not fat