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Research suggests oral B12 supplements (especially sublingual forms) can be just as effective as injections for treating deficiency

How Vitamin B12 Affects Brain Chemistry and Stress Systems Neurotransmitter production B12, together with folate and B6, is essential for the methylation reactions that produce serotonin, dopamine, norepinephrine, and GABA the neurotransmitters most directly involved in regulating mood, motivation, calm, and emotional stability

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How B12 Injections Work Unlike oral supplements, B12 injections deliver the vitamin directly into the bloodstream, bypassing the digestive system and ensuring better absorption

The catch is that B12 is one of the few nutrients you cannot get from an unfortified plant diet