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Conversely, loss of ROR disrupts bile acid rhythmicity, impairs FXRFGF15 signaling, reduces fatty acid oxidation, and produces severe hepatic steatosis, particularly under metabolic stress (44)

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Despite disadvantages, AMP have synergistic effects in combination with known antibiotics

El-Gebali S, Bentz S, Hediger MA, Anderle P

Individuals with diabetes, particularly those with T2D, not only showed an increased occurrence of steatosis but also notable liver fibrosis