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In certain autoimmune diseases such as anti-neutrophil cytoplasmic antibody-associated vasculitis, NSPs, especially PR3, participate as autoantigens in disease occurrence and development ( 9 Challenges and future prospects 9.1 Current challenges The development and clinical application of DPP1 inhibitors face multiple challenges that require resolution in future research

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First, acute and chronic EtOH administration induce overproduction of ROS, RNS and other free radicals, observations made in cell cultures, experimental animals and human subjects

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