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Novel unimolecular, multifunctional peptides have emerged as one of the most promising medicinal approaches to enhance metabolic efficacy and restore normal body weight
PAGln induces hypercontractility and altered Ca 2+ handling in cardiomyocytes The above physiological responses suggest that despite the lack of cardiac dysfunction as measured by echocardiography, there is a central effect of PAGln on the ability of the myocardium to contract and relax properly, manifesting as an elevation in LVEDP despite no change in afterload
1) Fights Oxidative Stress Glutathione reduces reactive oxygen species (ROS) and oxidative stress in the body, which would otherwise damage cells and DNA
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Biochemistry 30: 613619 [DOI] [PubMed] [Google Scholar] Molteni SN, Fassio A, Ciriolo MR, Filomeni G, Pasqualetto E, Fagioli C, Sitia R (2004) Glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum