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Strikingly, we observed a strong interaction between Ubx WT proteins, while the Ubx WT /Ubx N51A association was strongly reduced (Figure 2A)

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The slowed clearance of acid and gastric contents exacerbates mucosal irritation and symptom severity, frequently reported during the early stages of Wegovy treatment

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35 Notably, this protective effect appears to be dependent on the duration of treatment, with only a GLP-1RA treatment period exceeding 52 weeks being associated with decreased fracture risk