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However, these positive findings were not replicated in a larger adult population by Guo et al., 2022) demonstrating that 3 months of supplementation with fish oil (providing 2.34 g/day EPA + DHA) plus 1680 IU VD 3 significantly reduced serum ALT, triglycerides, IR, and inflammatory markers including IL-1 and TNF- compared to placebo, with no reported side effects, while the combination therapy showed additional benefits over fish oil alone for insulin sensitivity and inflammation
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Initially registered on April 19, 2022, it has never been inspected by the FDA