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For example, when the amount of mtROS produced by mitochondria changes due to hypoxia, mtROS enhances anaerobic respiration by stabilizing HIF-1 and up-regulating key enzymes of glycolysis such as lactate dehydrogenase, reduces the dependence of cells on OXPHOS during hypoxia, and reduces the further production of mtROS

linked to how the body expends energy

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Inflammatory cytokines secreted by these macrophages and T lymphocytes can modify endothelial function, SMC proliferation, collagen degradation, and thrombosis (43)