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Its high hydrophobicity, time-dependent aqueous solubility, aversion to alkaline pH, and significant photo-and thermolability have challenged pharmaceutical formulations (289)

It occurs naturally in human plasma, with levels that decline with age

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Further investigation into the testicular microenvironment using a co-culture system of senescent TM3 Leydig cells and GC-1 spg spermatogonia revealed that H2O2-induced senescent TM3 cells secreted increased levels of SASP factors, particularly IL-6 and TGF-

Statistical analysis