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The SURPASS-2 trial put tirzepatide head-to-head with semaglutide 1.0 mg in type 2 diabetic patients tirzepatide at all three doses (5 mg, 10 mg, 15 mg) outperformed semaglutide on weight loss and A1C reduction

Both manufacturers recommend stopping treatment at least 2 months before a planned pregnancy

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Relevant for OA patients: the 9mg dose produced nearly comparable pain reduction (75.8% vs 73.3%) with substantially lower dysesthesia incidence (8.8% vs 20.9%)