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Larazotide works complementarily by binding claudin receptors to restore the tight-junction barriers that, when compromised, allow bacterial endotoxins from periodontal pathogens to penetrate systemic circulation

Journal of Applied Toxicology,1995 141

Diabetologia 67:561566

However, if extremely high doses are given for a long time, pyridoxine can cause nerve damage leading to numbness or tingling in the hands and feet (peripheral neuropathy)