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Additional findings include the presence of epithelial cell-derived proteins associated with ferroptosis in plasma exosomes from pSS patients, the potential involvement of complement C5 and C9 in ferroptosis, and variations in the levels of ferroptosis-related proteins in the exosomes being more reflective of epithelial cell pathology compared to plasma

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In detail, it has been demonstrated that acetylation of histone H4 was diminished in rat hippocampus was reduced at the glutamate receptor 2 (GluR2) promoter after SE and H4 deacetylation appeared prior to GluR2 mRNA downregulation