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Although the exact pathophysiology of NAION is unknown, it is understood to result from insufficient blood flow to the optic nerve head, the researchers wrote in their paper

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A balanced appraisal of all these hypotheses is essential to draw appropriate conclusions from the available evidence

They are pharmacy-prepared formulations using the active pharmaceutical ingredient, but they are not FDA-approved, have not been evaluated for bioequivalence, and may differ in formulation, concentration, and composition

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