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This set of adults had a significantly greater risk for this outcome than each second-line diabetes medication group: any non-GLP-1RA second-line medication prescription (aHR = 1.29

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Small increases in the costs of treating cardiovascular and renal complications with oral semaglutide versus dulaglutide were due to increased survival of patients over the long term, who required further treatment of costly complications such as peripheral vascular disease, myocardial infarction and end-stage renal disease

Brown JM, Hazen SL