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The condition is more common in men, particularly those with African, South American, Middle Eastern, Mediterranean, or Asian ancestry

Valproate inhibits the mitochondrial pyruvate-driven oxidative phosphorylation in vitro

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discussion 36

Mice challenged with lipopolysaccharide/ Brucella abortus for 19 days exhibited an increase in immobility time, hyperalgesia, and serum TNF- levels