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The authors disclose support for this work from national funds through the Portuguese Foundation for Science and Technology [CICS-UBI, UIDB/00709/2020 and ProMETAB, 029114 projects

For now, it seems that by not choosing and by reducing their innovation efforts, many are risking being in neither.

Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury: Roles of cytochrome c, Bax, bid, and caspases

Moreover, lifestyle interventions such as optimizing nutritional intake and maintaining adequate sleep quality, in combination with pharmacological strategies, when necessary, can further mitigate the risk of decompensation (259)

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A small observational study (2023) in the journal *Obesity* suggested additive weight loss in a cohort of 47 patients on both agents, but sample size, lack of randomization, and absence of long-term follow-up prevent firm conclusions