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These findings not only enrich the molecular understanding of senescent cell clearance but also provide a novel strategy for precise targeting of endothelial cell senescence in therapeutic applications

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14,15 Using the formula for comparing two means, with a two-sided = 0.05 and power = 80%: the minimum required sample size to detect a difference in HbA1c was 39 patients per group (78 total) and the minimum required sample size to detect a difference in BMI was 48 patients per group (96 total)