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Therefore, the glycaemic improvement in animals treated with a GLP-1R/GcgR co-agonist is attributable to body-weight-independent and -dependent effects

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European Journal of Nuclear Medicine and Molecular Imaging

This is particularly concerning given that people with obesity-related comorbidities may reap the greatest benefit from treatment. Thomsen noted the irony that patients most likely to benefit from sustained treatment were often those most likely to abandon it due to side effects or other health complications

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