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Targeting p53 presents a substantial risk of off-target effects

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10.1111/nmo.14050 Neurogastroenterol Motil

Int J Mol Sci 23:13043

At the same time, the decreased cytotoxicity of the substrate drug, paclitaxel, can be enhanced to a similar level with the known MRP7 inhibitor cepharanthine and even similar to the cytotoxicity in the parental SKOV3 cells (Table 5)